The American Association of Endocrine Surgeons, Patient Education Site

Pancreatic neuroendocrine tumors: somatostatinoma

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What is the treatment of a somatostatinoma?

Since somatostatinomas have a high malignant potential, aggressive intervention is warranted. Surgical excision offers the only opportunity for long-term cure. Five year survival approaches 100% following complete resection in the absence of metastatic disease, while five year survival in the range of 60% overall is seen in patients with metastatic disease at diagnosis. Resection strategies may include distal subtotal pancreatectomy, pancreaticoduodenectomy (Whipple procedure), or, for smaller duodenal tumors, local excision. These tumors tend to be slow growing, and debulking of extensive disease may offer symptomatic relief and extend survival.


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