Treatment of Metastatic Neuroendocrine Tumors 

Patients with metastases from a neuroendocrine cancer may become symptomatic from hormone hypersecretion, rather than from tumor bulk. Approximately 10 to 30 percent of pancreatic neuroendocrine tumors secrete hormones that can result in clinical syndromes.  In particular, patients with small bowel or appendiceal carcinoid tumors may develop carcinoid syndrome, typically after development of hepatic metastases that…

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